Evaluation of molnupiravir (EIDD-2801) efficacy against SARS-CoV-2 in the rhesus macaque modelArticle Published on 2023-01-012023-07-11 Journal: Antiviral Research [Category] COVID19(2023년), [키워드] COVID-19 EIDD-2801 Molnupiravor non-human primate rhesus macaque SARS-CoV-2. [DOI] 10.1016/j.antiviral.2022.105492 PMC 바로가기
Recombinant Simian Varicella Virus-Simian Immunodeficiency Virus Vaccine Induces T and B Cell Functions and Provides Partial Protection against Repeated Mucosal SIV Challenges in Rhesus MacaquesArticle Published on 2022-12-172023-06-02 Journal: Viruses [Category] 두창, 수두, [키워드] protection rhesus macaque SIV Vaccine varicella virus-vector. [DOI] 10.3390/v14122819 PMC 바로가기
Recombinant Simian Varicella Virus-Simian Immunodeficiency Virus Vaccine Induces T and B Cell Functions and Provides Partial Protection against Repeated Mucosal SIV Challenges in Rhesus MacaquesArticle Published on 2022-12-172023-06-02 Journal: Viruses [Category] 두창, [키워드] protection rhesus macaque SIV Vaccine varicella virus-vector. [DOI] 10.3390/v14122819 PMC 바로가기
Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaquesSARS-CoV-2 초기 감염된 붉은털 원숭이의 여러 기관의 차등 전사체 풍경Article Published on 2022-12-012022-09-11 Journal: Protein & Cell [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] accompanied analyzed Angiogenesis cause Central nervous system cerebral cortex changes in clinical complications clinical manifestation clinical manifestations CNS Coagulation controls drastic dysregulation early infection elevated Encephalitis evidenced examined exhibited expression expressions Factor fibrosis function Genes hyperinflammatory state immune response immune responses infected with SARS-CoV-2 Infection Inflammation inflammation response Inflammatory factor inflammatory factors mechanism multiple organ neuropilin 1 NRP1 organs positive positive feedback post infection provide receptor rhesus rhesus macaque right ventricle SARS-CoV-2 SARS-COV-2 infection significantly tissue tissues transcriptomic transcriptomic alteration Transmission up-regulated upregulation Viral viral encephalitis viral encephalitis. [DOI] 10.1007/s13238-022-00915-5 PMC 바로가기 [Article Type] Article
Safety and immunogenicity of the first Kazakh inactivated vaccine for COVID-19Article Published on 2022-11-302022-11-15 Journal: Human vaccines & immunotherapeutics [Category] SARS, 진단, [키워드] adverse effect animal models antibody Antibody titer BALB/c mice changes in class COVID-19 COVID-19 vaccine demonstrated did not produce ELISA ENhance enzyme-linked immunosorbent ferrets Gender general condition GMT group growth hamster hamsters Health histology immune response immunization immunogenicity Inactivated vaccine injection internal organ Kazakhstan lowest microneutralization MNA nontoxic preclinical trials rhesus macaque Safety significant difference statistically significant Toxicity Vaccine vaccine. were assessed [DOI] 10.1080/21645515.2022.2087412 PMC 바로가기
B.1.351 SARS-CoV-2 Variant Exhibits Higher Virulence but Less Viral Shedding than That of the Ancestral Strain in Young Nonhuman PrimatesArticle Published on 2022-10-262022-11-16 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] addition Alpha animal model association B.1.351 Beta caused changes in Characteristics Chinese circulating Clinical signs contribute determine distribution drugs early stage Efficacy and safety elevated exhibited IFN-γ IL-17 Infection Inflammatory Inflammatory cytokine interferon gamma interleukin 17 investigated less Lower respiratory tract lung tissue mechanisms mutated Necrosis NHP NHPs nonhuman primate pathogenesis of SARS-CoV-2 pathogenic pathogenicity pathological changes primate provide pulmonary inflammation reduced replicated Research rhesus macaque SARS-CoV-2 SARS-CoV-2 strain SARS-CoV-2 vaccine SARS-CoV-2 variant SARS-CoV-2 variants severe lung injury shedding spike-specific T-cell response strain Strains tissue TNF-α Transmission upper respiratory tract Vaccine variant variants of concern viral distribution viral shedding virulence virulence. virulent VoC VOCs were infected [DOI] 10.1128/spectrum.02263-22 PMC 바로가기
Accelerating model-informed decisions for COVID-19 vaccine candidates using a model-based meta-analysis approachArticle Published on 2022-10-012022-11-15 Journal: EBioMedicine [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Analysis applied approach calibrated candidate carried clinical Clinical efficacy clinical trial convalescent CoronaVac COVID-19 COVID-19 pandemic COVID-19 vaccine develop Efficacy humans immunogenicity data Inc. joint literature review LLC Meta-analysis Model-based meta-analysis (MBMA) modelling Modelling and simulation Neutralizing predict predicted Predictive Predictive model Quantitative reported rhesus macaque Safe SARS-CoV-2 SARS-CoV-2 vaccines serum Sharp strain Study design Support systematic literature search the mean titre translation translational USA vaccination Vaccine vaccine candidate Vaccines. variant Viral load were used [DOI] 10.1016/j.ebiom.2022.104264 PMC 바로가기
mRNA-1273 vaccination protects against SARS-CoV-2-elicited lung inflammation in nonhuman primatesmRNA-1273 백신 접종은 비인간 영장류에서 SARS-CoV-2 유발 폐 염증으로부터 보호합니다Article Published on 2022-07-082022-09-11 Journal: JCI Insight [Category] COVID19(2023년), SARS, 변종, [키워드] 48 hour 48 hours Antibody Response Antibody responses Antibody titer Bronchoalveolar lavage fluid CCL3 cellular Cellular immune response chemokines collected correlated COVID-19 CXCL10 dissemination dose-dependent manner expression Genes Human IFIT1 immune immunology immunology. independent induction Inflammation Inflammatory ISG15 less limit Lower respiratory tract lung Lung inflammation mRNA mRNA-1273 MX1 observation Pathogenesis profile PROTECT replicated respiratory tract restrict viral replication rhesus macaque rhesus macaques SARS-CoV-2 SARS-CoV-2 antibody response SARS-CoV-2 antibody responses SARS-CoV-2 spike SARS-CoV-2 strain serum Support suppressed These data transcriptomic USA-WA1/2020 vaccination Vaccine-induced immunity variant of SARS-CoV-2 viral infection viral replication Viral RNA [DOI] 10.1172/jci.insight.160039 PMC 바로가기 [Article Type] Article
Modelling the response to vaccine in non-human primates to define SARS-CoV-2 mechanistic correlates of protectionSARS-CoV-2 보호의 기계적 상관 관계를 정의하기 위해 인간이 아닌 영장류에서 백신에 대한 반응 모델링Article Published on 2022-07-082022-09-12 Journal: eLife [Category] COVID19(2023년), MERS, SARS, 진단, [키워드] ACE2 appear approach binding Cell clearance Correlate of protection Critical decrease identify immunological immunology increase in infected cells Infection Inflammation inhibition main mechanism Mathematical modelling mechanism mRNA neutralization non-human primate RBD binding reduction in required rhesus rhesus macaque robust SARS-CoV-2 SARS-CoV-2 vaccine to define Vaccine vaccine platform Vaccines viral dynamics viral replication viruses viruses. [DOI] 10.7554/eLife.75427 PMC 바로가기 [Article Type] Article
Rapidly developable therapeutic-grade equine immunoglobulin against the SARS-CoV-2 infection in rhesus macaques붉은 털 원숭이의 SARS-CoV-2 감염에 대한 신속하게 개발 가능한 치료 등급 말 면역 글로불린Article Published on 2022-07-072022-09-12 Journal: Signal Transduction and Targeted Therapy [Category] Coronavirus, COVID19(2023년), MERS, SARS, 비임상, 진단, [키워드] equine Immunoglobulin Infection rhesus macaque the SARS-CoV-2 [DOI] 10.1038/s41392-022-01095-8 PMC 바로가기 [Article Type] Article